TBK1 and amyotrophic lateral sclerosis: To assess whether TBK1 activation is altered in ALS, we measured total TBK1 and phospho-TBK1 in patients' LCLs heterozygous for TBK1 variants: p.T31A, c.992+1G>A (p.G272-T331del), p.R358H, p.Q565P, p.E643del, and 7 control LCLs.