The role of that agent in the allergic reaction is proved by works describing role of corticosteroids in promotion of ventriculoperitoneal shunt survival by blocking the effect of eosinophil meaning as production, migration, and/or granule release, by inhibiting the production and/or release of IL-5 in the bone marrow, and preventing chemoattractant production and upregulation of adhesion molecules [17]. The gene discussed is IL5; the disease is allergic disease.