Regarding HSPB8, K141E hot-spot mutation causes autosomal-dominant distal hereditary motor neuropathy (distal HMN type IIA, OMIM 158590) [27], whereas its variant (K141N) causes Charcot–Marie–Tooth disease type 2L (CMT2L, OMIM 608673) [47]. Here, HSPB8 is linked to neuronopathy, distal hereditary motor, autosomal dominant.