In our study, HF feeding decreased cholesterol metabolism gene mRNA expression of lecithin cholesterol acyltransferase (LCAT), and increased cholesterol synthesis speed limiting enzyme HMGR and peroxisome proliferator-activated receptor gamma (PPARγ), whereas Se and Mg co-supplementation significantly increased the levels of expression of LCAT mRNA and decreased that of HMGR (P < 0.05). Here, PPARG is linked to hydrops fetalis.