Table 3 shows the association between plasma ApoE and the risk of EBB-induced bleeding after adjusting for the location of the lesion, histological types, stage, smoking history, HDLC, and CRP level (adjust I), and on combined adjustment of risk factors judged by clinical significance (age, sex, diabetes, hypertension, COPD, CHD, SBP, DBP, TC, triglyceride, LDLC, ALT, and AST) (adjust II). The gene discussed is APOE; the disease is hypertensive disorder.