Our study found that plasma ApoE levels associated well with the incidence of EBB-induced bleeding after adjustment for the main confounding risk factors (HDLC, smoking, location of lesion, histological types, stage, and CRP), or on combined adjustment for factors considered to be clinically relevant (sex, age, SBP, DBP, TC, triglyceride, LDLC, diabetes, hypertension, COPD, CHD, ALT, and AST); the strength of this association did not change. The gene discussed is APOE; the disease is hypertensive disorder.