HMGB1 and osteoarthritis: Beside these, other regulators were also affected by δ-tocotrienol treatment of hepatitis C patients, and they are interferon signaling, IL-2 signaling, and HMGB1 signaling, Cardiac hypertrophy signaling, Th1 and Th2 activation pathway, production of nitric oxide and reactive oxygen species in macrophages, Osteoarthritis pathway, PPAR signaling, type,I diabetes mellitus signaling, Type II diabetes mellitus, and insulin receptor signaling.