FTO is not the only demethylase with a link with AML; METTL14 also plays an important oncogenic role in this disease by regulating its mRNA targets (e.g., MYB, MYC) through m6A modifications, which in turn leads to enhanced MYB and MYC expression and ultimately blocks myeloid differentiation [48]. Here, FTO is linked to acute myeloid leukemia.