FTO and acute myeloid leukemia: FTO levels in certain subtypes of AML (e.g., t(11q23)/MLL-rearranged, t(15;17), FLT3-ITD, and/or NPM1-mutated) are abnormally elevated, which leads to the downregulation of m6A levels on the UTRs of ASB2 and RARA [47].