In this study, we showed that LINC00152 was upregulated in ovarian cancer tissues and cell lines, and knockdown of LINC00152 inhibits cell proliferation, induces apoptosis in vitro, and suppresses tumor growth in vivo, by acting as a ceRNA of miR‐125b to regulate its targets within the MCL‐1‐mediated mitochondrial pathway. Here, MCL1 is linked to ovarian carcinoma.