APAF1 and ovarian cancer: Furthermore, upregulation of GAS5 inhibits ovarian cancer growth through regulating apoptosis protease activating factor 1 (APAF1), cyclin D1, and p21 levels.4 The antisense lncRNA HOXA11 had higher expression levels in ovarian cancer tissues than compared to normal tissues, as well as a positive correlation with histological grade, suggesting that it is a prognostic factor of progressive disease and mortality.