The lncRNA was equipped with 2 active domains, including 5′‐end that could recruit PRC2, and 3′‐end that combined with lysine specific demethylase (LSD1), RE1‐silencing transcription factor (REST) and REST co‐inhibitory protein (CoREST).43 It was also involved with epigenetic modulation of genes, and its interaction with polycomb repressive complex 2 (PRC2) turned as a crucial process within various cellular pathways.44 Our study also demonstrated that HOTAIR acted as an oncogene for promoting retinoblastoma development (Figures 3, 4). Here, HOTAIR is linked to retinoblastoma.