For instance, HOTAIR was previously demonstrated to alter the proliferative efficiency of neoplasms through modulating p21 expression, and p14 or p16‐dependent pathways.54, 55 It was suspected that the regulatory effects exerted by HOTAIR on tumour onset and progression differed with tumour type, so further validations should be performed through both in‐vivo and in‐vitro investigations. This evidence concerns the gene HOTAIR and neoplasm.