However, Ang II-induced increases in serum creatinine and blood urea nitrogen were significantly mitigated by PI3Kγ inhibitor AS605240 (p < 0.01 and p < 0.05 respectively) (Fig. 1B,C), suggesting that PI3Kγ blockade may be beneficial to preservation of kidney functions during renal hypertension. This evidence concerns the gene AGT and renal hypertension.