C9orf72 and amyotrophic lateral sclerosis: We asked if global or specific alterations in RNA stability are characteristic of ALS by applying Bru-seq and BruChase-seq24 to 14 fibroblast cell lines obtained from individuals with C9orf72-linked familial ALS (C9ALS, four lines), sporadic ALS (sALS, five lines), or controls (five lines; Supplementary Table 1).