TARDBP and amyotrophic lateral sclerosis: Given the enrichment for TDP-43 motifs among transcripts showing altered stability in ALS iPSCs (Supplementary Fig. 9), the critical function of TDP-43 in RNA splicing10,11,18, and the central connections between TDP-43 deposition and neurodegeneration in both sALS and C9ALS3,5, we surmised that TDP-43 accumulation could contribute to RNA instability in ALS patient cell lines.