RAF1 and chronic kidney disease: The RAF inhibitor PLX4720 (vemurafenib) induced much less luciferase signaling in 293T transfectants that express either Cluc-CKD/S621A, Cluc-CKD ΔC, or Cluc-CKD/R401H, in contrast to those expressing the WT counterpart (Fig. 2C), suggesting that CKD/S621A and CKDΔC have much less ability than CKD/R401H to associate with CKD upon inhibitor loading.