NEFM and amyotrophic lateral sclerosis: We established that a small group of ALS-linked miRNAs (miR-9-5p, miR-20b-5p, miR-92a-3p, miR-125b-5p and miR-223-3p) directly down-regulate human NEFM and NEFH mRNA levels, an effect that is translated into a reduction of NFM and NFH protein levels within spinal cord homogenates.