In concert with the observations of this study, we hypothesize that in ALS spinal cords the sustained dysregulation in time of the expression of groups of miRNAs that control NF levels fundamentally alters the expression of all three NF transcripts in a manner that induces an alteration in the stoichiometry of the individual NF proteins, favoring the formation of pathological NCIs. The gene discussed is NFASC; the disease is amyotrophic lateral sclerosis.