LRP12 and neoplasm: In our study, the tumor suppressor gene LRP12 (LDL receptor-related protein 12) featured among the strongest fold changes in methylation and correlation to carboplatin response with a distinct hypermethylation (log2FC 2.65, p value 0.009, Spearman correlation 0.52, p value 0.01) and downregulation in the resistant tumors.