HOXD10 and non-small cell lung carcinoma: Accordingly, the promoters of several HOX genes (HOXD12, HOXD10), which are known to be regulated by polycomb repressor complex 2 (PRC2), were among the most significantly hypermethylated regions (data not shown), confirming previous results implying a role of DNA methylation in PRC2 dysregulation in NSCLC [42, 43].