To validate the methylation changes of LRP12 and to extrapolate the finding from the PDX mouse models to clinical samples, we analyzed the methylation status of LRP12 in an independent patient cohort by applying quantitative methylation-specific PCRs (qMSP) to formalin-fixed paraffin-embedded (FFPE) primary NSCLC tumors. The gene discussed is LRP12; the disease is non-small cell lung carcinoma.