Of significance, cell markers that were previously identified to be associated with a more stem cell-like state in HNSCC (DNAJC6, NR5A2, HELLS, KRT5, and KRT14), and characterized by elevated β-catenin activity [20, 44], were also found to be significantly downregulated by ICG-001 in HSC-3 cells (Fig. 2c and Fig. 3a). The gene discussed is HELLS; the disease is head and neck squamous cell carcinoma.