SMAD4 and neoplasm: Concordance between mutations in the primary tumour and the synchronous liver metastasis was seen in APC, KRAS, NRAS, TP53 and BRAF genes (100%), while discordance among those with a mutation was seen in, amongst others, PIK3CA (50%), AHNAK2 (20%), SMAD4 (17%), BCLAF1 (50%), and ARHGAP32 (100%).