A recent study by Sierra et al. has shown that humanized anti-Jagged1/2 suppressed tumor growth, decreased the accumulation and tolerogenic activity of MDSCs in tumors, and inhibited the expression of immunosuppressive factors, iNOS and arginase, which in turn, promoted CD8+ T cell infiltration into tumors, and improved the in vivo efficacy of T-cell based immunotherapy [54]. The gene discussed is JAG1; the disease is neoplasm.