In two independent cohorts of women with familial breast cancer [28] and axillary node-negative (ANN) breast cancer [29], we have observed that T-bet+ tumor-infiltrating T lymphocytes (T-bet+ TILs) were associated with adverse clinicopathological features such as large tumor size, high grade, mutant p53, ER negativity, CK5 positivity, EGFR positivity, and basal molecular subtype [29, 30]. Here, ESR1 is linked to neoplasm.