This finding, in addition to the positive association between Jagged1 and T-bet+ TILs observed in this study, suggests that in BRD4+/high, T-bet+/high tumors, BRD4-mediated upregulation of Jagged1 may reinforce the anti-tumoral activity of T-bet+ TILs, and facilitate disease-free survival of patients with breast cancer. The gene discussed is JAG1; the disease is breast carcinoma.