Hence, in a T-bet+ TIL-mediated tumor microenvironment, BRD4-mediated NF-kB activation, and subsequent proinflammatory cytokine production may contribute to tumor suppression as the pro-inflammatory cytokines have shown to be important in recruiting circulating leukocytes and activating CD4+ T cell functions. The gene discussed is NFKB1; the disease is neoplasm.