Hence, BRD4+/high tumors in the absence of T-bet+ TILs may exhibit BRD4-mediated upregulation of Jagged1 that may induce Jagged-1-Notch1-mediated accumulation and activation of MDSCs, and suppress the infiltration and anti-tumor activity of T-bet+ T cells. The gene discussed is BRD4; the disease is neoplasm.