SIRT1 and blepharophimosis, ptosis, and epicanthus inversus syndrome: On one hand, the single female patient in this affected family is still too young to pathologically classify the BPES subtype; on the other hand, the experimental approach we employed in this study was completely different than those used by Dipietromaria et al. (StAR-luciferase construct rather than the dual 4xFLRE-luc/SIRT1-luc reporters) [24], making it impossible to compare the transactivation capacity of p.H311Y.