Interestingly, the histidine 311 residue of FOXL2 protein is highly conserved across species (Fig. 1d) while the Grantham distance score (83) between histidine and tyrosine is high [20], suggesting this amino acid substitution might have a functional impact on FOXL2 protein and subsequently the pathogenesis of BPES. The gene discussed is FOXL2; the disease is blepharophimosis, ptosis, and epicanthus inversus syndrome.