Moreover, 12 genes in the FI network belonged to the 72 identified key nodes, such as CCL20, HDAC10, FPR2 and PRKACA. Besides, the 12 genes were also the key genes in 4 module networks correlating with pathways of integration of energy metabolism (module a), GPCR-related pathways (module b), RNA binding-related pathways (module c), alcoholism and chromatin modifying enzymes (module d). Here, HDAC10 is linked to alcohol dependence.