Since uncleaved and non-native forms of Env bind to non-NAbs [6–8] and may aid in immune evasion during HIV-1 infection by eliciting non-NAbs [9, 10], the current focus for designing immunogens is based on generating native, cleaved forms of Envs [6, 11, 12]. This evidence concerns the gene ERVW-1 and HIV-1 infection.