Although crizotinib-induced ILD in ROS1-positive NSCLC patients has not been systematically characterized before, patients with ROS1 rearrangements had a similar incidence (1.9%, 1 of 53) of ILD as those containing ALK rearrangements (1.7%, 2 of 119) in a phase I PROFILE 1001 study of crizotinib [3]. This evidence concerns the gene ROS1 and interstitial lung disease.