Two independent reports demonstrate a role for miR-877 as a tumor suppressor in renal cell carcinoma by targeting eukaryotic elongation factor-2 kinase (eEF2K), and in myofibroblast differentiation and bleomycin-induced lung fibrosis by targeting targets Smad7 [65,66]. The gene discussed is EEF2K; the disease is hereditary clear cell renal cell carcinoma.