NLGN3 and autism spectrum disorder: Moreover, a recent study showed that neuroligin-3 (Nlgn3) mutations selectively impaired dSPNs in nucleus accumbens (NAc) to boost autism spectrum disorder (ASD)-associated repetitive behaviors, suggesting the malfunction of Nlgn3 positive synapses in NAc dSPNs may be a driver of at least some behavioral symptoms in ASD [26].