Among these, several stromal ECM proteins, COL1A1, COL1A2, COL3A1, COL5A1, COL5A2 and proteoglycans LUM, DCN, and FMOD (Table, a complete list of detected proteins may be accessed at https://www.ebi.ac.uk/pride/, in the public domain), were decreased in the KC cell proteome, as already revealed by our biochemical analyses for some of these. The gene discussed is COL5A2; the disease is keratoconus.