Thus, extracts of KC fibroblasts show elevated p-eIF2α (0.35 ± 0.03 KC vs. 0.18 ± 0.03 DN), accompanied with elevated CALR (0.35 ± 0.02 vs. 0.69 ± 0.1; P = 0.02) as seen before for KC keratocytes. The gene discussed is EIF2A; the disease is keratoconus.