BIN1 and hydrops fetalis: However, previous work from several laboratories has also implicated decreased expression of JPH-2 and BIN-1 in the altered t-tubule structure observed in HF (13, 24, 42, 43), and it is notable that the changes observed in the present study were smaller than those typically observed in HF, despite complete ablation of Cav-3 compared with the ~40% decrease reported in HF (11).