Oxidative stress in DS has been linked to particular proteins encoded by genes located in Hsa21 that are overexpressed or whose activity is deregulated, namely superoxide dismutase 1 (SOD1), the regulatory kinase Dyrk 1A (DYRK1A), the transcription factor Ets‐2, or the amyloid precursor protein (APP); all of which are directly or indirectly inducers of ROS (Busciglio et al., 2002; Rodríguez‐Sureda et al., 2015; Wolvetang et al., 2003). The gene discussed is ETS2; the disease is Dravet syndrome.