As PKCδ can be activated by caspase 3 (Casp3) cleavage (Anantharam et al., 2002), we incubated PQ‐treated DS HF with the Casp3‐specific inhibitor Z‐DEVD‐FMK for 12 hr, preventing Nrf2 nuclear translocation (Figure 3e). This evidence concerns the gene PRKCD and hydrops fetalis.