CACNA1C and Familial short QT syndrome: A patient with BrS, who has a p.V2014I mutation in CACNA1C, also had a p.D601E polymorphism in CACNB2b, and this polymorphism dramatically augmented the late calcium current of LTCC, which prolonged the QT interval, the modulatory effect of this single nucleotide polymorphism probably interprets the fact that QTc in this proband is not associated with SQTS [102].