CACNA1C and hypertrophic cardiomyopathy: Recently, a novel CACNA1C mutation p.R1937P was reported in a Chinese family of hypertrophic cardiomyopathy with early repolarization and SQTS, p.R1937P induced the loss-of-function of CaV1.2 channels, which dramatically decreased the ICa and hyperpolarized the SSI [116].