Representative image (Fig. 1A) and quantitation of normalized total flux (Fig. 1B) showed statistically significant reduction in jawbone‐localized bioluminescent signal in PC3M‐Luc shMTA1 compared to NS control xenografts, suggesting that MTA1 depletion significantly compromised the colonization of PC3M prostate cancer cells to the bone. Here, MTA1 is linked to prostate carcinoma.