MTA1 and Familial prostate cancer: Our group has intensively published on pharmacological inhibition of MTA1 and its associated signaling by natural dietary compounds such as resveratrol and pterostilbene as well as PI3K and histone deacetylase inhibitors resulting in targeted chemoprotective and anticancer effects in various prostate cancer model systems including xenografts and transgenic mice (Butt et al., 2017; Dhar et al., 2015a,b, 2016, 2017; Kai et al., 2010; Kumar et al., 2015; Levenson et al., 2014; Li et al., 2013).