Most importantly, disruption of the autophagic flux by CQ sensitizes neuroblastoma cells to the 14G2a mAb-induced apoptosis, as assessed by an increase of cleaved-caspase 3, cleaved PARP, and pro-apoptotic Bax protein level signals to 7.5, 3.7 and 2.0, respectively (Fig. 4a, b). This evidence concerns the gene BAX and neuroblastoma.