Obesity or overnutrition during pregnancy leads to maternal immune activation (MIA), which favors changes in plasma and placental tissue-specific lipidomic profile, recruiting lipid species to membrane Toll-Like Receptor 4 (TLR4) and activating the nuclear factor-kappa B (NF-κB) pathway, through an increase of TLR2, TLR4, IL-6, IL-18, and TNF-α mRNA levels and macrophage markers cluster of differentiation including (CD)11b, CD14, and CD68 [68–70]. Here, TLR4 is linked to obesity due to melanocortin 4 receptor deficiency.