In more recent studies, the overexpression of SULFs in a wide range of tumors has been reported through quantitative PCR or gene microarray: SULF1 is upregulated in hepatocellular carcinoma [81], gastric cancer [82], head and neck carcinoma [83], pancreatic cancer [84], and lung adenocarcinoma [85], and SULF2 is highly expressed in hepatocellular carcinomas [86] and lung carcinoma [85], among others. This evidence concerns the gene SULF2 and hepatocellular carcinoma.