GNRH1 and Familial prostate cancer: Similarly, Klotz et al. evaluated the efficacy of combining CAB therapy with bicalutamide 50 mg using validated statistical methodology to combine the Prostate Cancer Trialists’ Collaborative Group meta-analysis data [13] with data from a phase 3 trial of two CAB regimens (GnRH agonist plus bicalutamide 50 mg versus GnRH agonist plus flutamide) [14].