Although the primary and secondary endpoints of this trial—reduction in disease activity at week 24 by BILAG (primary) and SRI (secondary)—were not met, an exploratory analysis showed that rontalizumab treatment was associated with an improvement in disease activity, reduced flares, and decreased corticosteroid use in patients with SLE with low IFN signature. Here, IFNA1 is linked to systemic lupus erythematosus.