PNLIP and Insulin resistance: The efficacy of tea polyphenols (e.g., catechins: epigallocatechin gallate, EGCG) in regulating multiple targets concludes in inhibiting pancreatic lipase activity, reducing nutrient absorption, impairing adipogenesis, suppressing appetite, enhancing cellular oxidation defenses, activating AMP-activated protein kinase in the skeletal muscle, adipose tissues, and liver, and improving systemic inflammation, hyperglycemia, and insulin resistance [56–59].