DDX53 and neoplasm: For example, the two immunodominant epitopes from the transplantable murine tumor CT26 have half-lives of 60 and 20 min [H-2Ld binding SPSYVYHQF and H-2Dd binding GGPESFYCASW respectively (47)], despite there being almost 500 neo-epitopes generated from point mutations that are considered likely to be immunogenic as they have an IEDB percentile rank less than or equal to 1% [(48); Table S3 in Supplementary Material].