Our model could also be used to simulate peptide presentation in tumor escape mutants with altered expression of: (i) some of the immunoproteasome sub-units (LMP2 and LMP7) that would maintain a “non-inflammatory” peptidome even in the presence of IFNγ; (ii) proteins involved in the IFNγ signaling pathway (50) also resulting in the presentation of a “non-inflammatory” immunopeptidome within a pro-inflammatory tumor microenvironment; (iii) mutations affecting the expression of antigen processing and presentation molecules, including TAP, tapasin, and ERAAP. This evidence concerns the gene PSMB9 and neoplasm.