The serum concentrations of PGRN in the SCH group (42.0 ± 7.3 ng/ml) and CH group (39.6 ± 3.1 ng/ml) were significantly higher than that in the NC group (30.7 ± 8.5 ng/ml) (P < 0.05), which was in accordance with the results of Western blot. The gene discussed is GRN; the disease is cyclic hematopoiesis.