Elevated levels of inflammatory markers, such as ROS, NF-κB, TNF-α, IL-1β, and COX metabolites in patients with OSA and IH-exposed animals have been reported (Kent et al., 2011; Yang et al., 2016a; Fernandez-Julian et al., 2017). This evidence concerns the gene NFKB1 and obstructive sleep apnea syndrome.