Numerous works show that the increased JNK phosphorylation and activation of JNK-dependent pathway occur after global and focal cerebral ischemia in rats and mice (Hayashi et al., 2000; Irving and Bamford, 2002; Borsello et al., 2003; Ferrer et al., 2003; Tian et al., 2005; Atochin et al., 2016). Here, MAPK8 is linked to Cerebral ischemia.