However, a dual inhibitor of MAPKs JNK and p38, compound V-150 when administered prior to ischemia worsens cardiomyocyte apoptosis and myocardial infarction in the animal model of prolonged ischemia (Shao et al., 2006) emphasizing the relevance of focusing on the effects of selective JNK inhibitors. This evidence concerns the gene MAPK1 and ischemia.