MAPK8 and myocardial infarction: Pharmacological inhibition of JNK by various synthetic inhibitors, such as AS601245, SP600125, and SR-3306 (Table 1), reduces the size of myocardial infarction and attenuates cardiomyocyte apoptosis after ischemia/reperfusion injury (Yue et al., 2000; Ferrandi et al., 2004; Duplain, 2006; Liu et al., 2007; Milano et al., 2007; Liu et al., 2008; Song et al., 2008; Shi et al., 2009, Zhang J. et al., 2009; Xu et al., 2011; Chambers et al., 2013; Khan et al., 2017).