In the rat model of heart ischemia/reperfusion injury in vivo, administration of SP600125, an anthrapyrazolone inhibitor of JNK that competes with ATP to inhibit the phosphorylation of c-Jun, attenuates mitochondria-to-nuclear translocation of AIF, cardiomyocyte apoptosis, and the size of necrosis (Song et al., 2008; Zhang J. et al., 2009). The gene discussed is MAPK8; the disease is injury.