CREB1 and atrial fibrillation: Several other models overexpressing negative regulators of CRE-mediated transcription consistently showed atrial dilation (Fentzke et al., 1998; Okamoto et al., 2001; Kehat et al., 2006b), and downregulation of CREB target genes was connected to AF susceptibility in humans (Deshmukh et al., 2015).