IGF1 and retinal degeneration: Also, it is well known that IGF-1 actions are slowed during aging (Lee et al., 2013) and, as we have mentioned above, under this condition the deficiency of Igf1 in mice reflects an unbalanced anti-inflammatory vs. proinflammatory response in the retina that parallels the retinal degeneration (Arroba et al., 2016a).