On the other hand, another study has reported increased levels of insulin-like growth factor binding protein 2 (IGFBP-2) and IGF-1 in exudative AMD eyes, indicating that defects in the expression of IGF-related molecules may be involved in the disease pathogenesis for exudative AMD (Cha et al., 2013). Here, IGFBP2 is linked to age-related macular degeneration.