Regarding the involvement of the IGF-1 system in AMD, a case-control study involving 962 subjects showed that in non-diabetic individuals from the Age-Related Eye Disease Study (AREDS) Genetic Repository the SNP rs2872060 in the IGF-1R was significantly associated with the risk for advanced AMD and this association remained significant after patient stratification by the two types of the disease: neovascularization and geographic atrophy (Chiu et al., 2011). This evidence concerns the gene IGF1 and age-related macular degeneration.