Additionally, the interaction with pathognomonic aggregation-prone proteins, such as Aβ, α-syn, or tau needs further research, but the presence of LF aggregates within neurodegeneration-specific protein deposits such as the AD senile plaques suggests an involvement of LF in pathogenesis (Cataldo et al., 1994; Giaccone et al., 2011) (see also Figure 1). Here, MAPT is linked to Alzheimer disease.