The heptapeptide, angiotensin-(1-7) [Ang-(1-7)], final endogenous effector of ACE2-Ang-(1-7)-Mas pathway, has shown neuroprotection in several models of ischemic stroke (Zhang et al., 2008; Mecca et al., 2011; Bennion et al., 2015a, 2018). Here, MAS1 is linked to ischemic stroke.