On the other hand, induced-pluripotent stem cells (iPSC)-derived neurons carrying the 10 + 16 MAPT mutation (inducing altered tau splicing that causes FTD) present hyperpolarization of the mitochondria, which is partially maintained by the complex V working in reverse mode, leading to an increase in ROS production, oxidative stress, and cell death (Esteras et al., 2017). The gene discussed is MAPT; the disease is frontotemporal dementia.