In a number of human diseases called tauopathies, including Progressive Supranuclear Palsy (PSP), Pick’s disease (PiD), Down’s syndrome (DS), and Frontotemporal Dementia and Parkinsonism linked to chromosome 17 (FTDP-17), soluble tau assembles into insoluble filaments, leading to synaptic failure and neurodegeneration (Spillantini and Goedert, 2013). The gene discussed is MAPT; the disease is Down syndrome.