CD40LG and Waldenstrom macroglobulinemia: Whole-genome sequencing has identified highly recurring somatic mutations in patients with Waldenström’s Macroglobulinemia (WM) and IgM Monoclonal Gammopathy of Undetermined Significance (MGUS) [1, 2]: 76–100% of WM patients and 43–87% of those with IgM MGUS harbor a single point mutation in MYD88 gene (rs387907272), resulting in p.Leu265Pro (L265P) amino acid change [1–5].