Regarding the control group of non-IgM MGUS and MM patients, there were no MYD88 mutations detected in tDNA (8 out of 8 for MYD88 and 8 out of 8 patients for CXCR4) and cfDNA (6 out of 6 patients for MYD88 and 7 out of 7 patients for CXCR4). This evidence concerns the gene MYD88 and Miyoshi myopathy.