To examine PDGFRα as a target for the therapy of HCC, we synthesized several series of 2-phenyloxypyrimidine derivatives based on our previous finding that substitution of the 2-phenylaminopyrimidine core of imatinib with 2-phenyloxypyrimidine abolished the inhibition to most kinases, while preserved the inhibitory activity against PDGFRα12. Here, PDGFRA is linked to hepatocellular carcinoma.