KDR and hepatocellular carcinoma: Significant progress in the understanding of cellular and molecular mechanisms of HCC has provided a clear picture that hepatocarcinogenesis depends on aberrant activation of different RTKs, such as epidermal growth factor receptor (EGFR), VEGFR, PDGFR, fibroblast growth factor receptor (FGFR), and hence activate various intracellular signaling pathways19.