ENO2 and neoplasm: The results showed that there were four vital discrimination factors of malignant PNTs as followed, age ≤ 49 months, primary site of adrenal and thoracic, level of serum NSE > 33 ng/mL, and tumor encasing blood vessels, especially level of serum NSE > 33 ng/mL [OR, 36.154 (10.681, 122.379)] and age ≤ 49 months [OR, 19.049 (6.470, 56.088)].