Conversely, knockdown of ARMC12 reduced the enrichment of ARMC12, RBBP4, EZH2, and H3K27me3 on target gene promoters (Fig. 6a), and increased the expression of CADM1, EGLN3, HRK, HS6ST3, and SMAD9 in NB cells (Fig. 6b, c). Here, HRK is linked to neuroblastoma.