Notably, due to similar molecular weight and ARM2 domain (Supplementary Fig. 5a and Supplementary Fig. 5b), FLAG-tagged protein of two ARMC12 variants with low abundance was also able to interact with RBBP4 protein in SH-SY5Y cells (Supplementary Fig. 5c), and facilitate the anchor-independent growth and invasion of NB cells (Supplementary Fig. 5d and Supplementary Fig. 5e). Here, ARMC12 is linked to neuroblastoma.