In addition, silencing of RBBP4 or EZH2 prevented the elevated EZH2 activity and H3K27me3 levels induced by ARMC12 overexpression (Fig. 4f), while transfection of RBBP4 or EZH2 rescued the decreased EZH2 activity and H3K27me3 levels in NB cells with stable silencing of ARMC12 (Fig. 4f). The gene discussed is ARMC12; the disease is neuroblastoma.