Dysregulation of RBBP4 is linked to carcinogenesis in breast tissues38,39, and controls the human papillomavirus type 16 transforming activity in cervical carcinogenesis through regulating the expression of tumor suppressive (retinoblastoma and p53) or oncogenic (cyclin D1 and c-Myc) genes40. This evidence concerns the gene TP53 and neoplasm.