In order to examine whether alterations in the firing patterns and long-range synchrony of VTA neurons are associated with cognitive deficits, we recorded neural activity simultaneously in the VTA and medial PFC (Supplementary Fig. 1) of D2R-OE and control mice while they performed a delayed non-match to sample spatial WM task in a T-maze (Fig. 1a)21. This evidence concerns the gene DRD2 and Cognitive impairment.