NOD1/2 signaling contributes to gastro‐intestinal immunity (Philpott et al, 2014), and genetic variants in NOD2 are the strongest susceptibility factors to Crohn's disease—one of the two major inflammatory bowel diseases afflicting millions in Europe and North America alone (Hugot et al, 2001; Ogura et al, 2001; Ananthakrishnan, 2015). This evidence concerns the gene NOD2 and inflammatory bowel disease.