ACAD9 and hyperinsulinemic hypoglycemia, familial, 4: Based on the prevalence of deleterious ACAD9 alleles in the normal population (GnomAD, www.gnomad.broadinstitute.org, [33]) we estimated that approximately 59 children with ACAD9 deficiency will be born each year in Europe (for calculation see Additional file 3 Table S2).